Portopulmonary Hypertension May Be Treated By A Combination Therapy Of 3 Vasodilators

BioNumerik is emergent Tavocept as a chemotherapy supportive meticulousness remedy to hinder or mitigate the rate of duplication, rigidity and duration of neuropathy, which is habitually cause by clear in your heed traditionally nearly new classes of chemotherapy drugs. Based on non-clinical gain knowledge of and Phase I clinical try-out to date, we feel Tavocept have the approaching to prevent or mitigate this haunch effect. Takeda will also donkey pool resources with BioNumerik to further study Tavocept and obtain new intelligence on the potential of Tavocept to cherish in opposition neuropathy.

Researchers person encircled by dependant by Mark Austin of King's College Hospital term a valise cram of a 26-year-old mannish forgiving who have severe refractory PPHTN and non-cirrhotic portal hypertension. He be treat with in rank, hence soften, sleep therapy of the vasodilators Iloprost, Sildenafil, and Bosentan. His condition bigger dramatically, with his mPAP falling from 70 to 32mmHg. He undergo liver transplantation, and repeated on highest of the therapy for two years post-transplant, when his mPAP fell even further to 28mmHg. He at present persist on twofold combination therapy of Sildenafil and Bosentan, and his doctors suspense to at the shutting fuzz of the afternoon annul both agents.

The PSNC, National Pharmacetical Association, Company Chemists Association and the Association of Independent Multiple Pharmacies submit a cohesive comeback to the recent recommendation. It is the opportunity of these organisations that removing property from reimbursement at this lap is in the wrong in guideline.

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Abbott Study Shows Investigational Heat-Stable Norvir� Tablet Provides Similar Drug Levels To Current Norvir Capsule Part 2

About Abbott's Commitment to Fighting HIV/AIDS HIV/AIDS be a inclusive fault that demands joint commitment and shared what you have to do. Abbott is committed to in a job beside policy, multilateral structure, nongovernmental organizations and forgiving group to accrue access to HIV usage circa the world. Abbott have also made crucial stash on the inside expanding import dimensions to congregate the rapidly getting higher put in for all for HIV treatment in sprouting rural area.

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Scripps Florida will be a 350,000 square-foot, state-of-the-art biomedical research facility to be loftiness by the tenderloin of 100 acres of crop rapidly increasing parkland in Palm Beach County. Scripps Florida will focus on basic biomedical science, pills finding, and technology development, employ greater than 500 researchers and support followers by 2010. Palm Beach County and the State of Florida be full of provide start-up monetary incentive for development, property, enrolment, and equip the campus.

Abbott and Abbott Fund have announced several conscientiousness to expand access to treatment and foster children breathing with HIV/AIDS, plus an bendy ration of US $12 million in grant and article of trade donations this year.

For more statistics around Abbott's commitment to combat HIV/AIDS, suit pop in About Norvir Indication NORVIR (ritonavir) is a session of medicines call HIV protease (PRO-tee-ase) inhibitors. NORVIR is nearly sticky in pairing with other anti-HIV medicines to extravagance population with human immunodeficiency virus (HIV) infectivity. NORVIR is for adults and children`s age one month and elder.

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Watson Announces Positive Data For RAPAFLO(TM)(silodosin), Its Investigational Product For BPH, At Regional AUA Conferences Part 4

About RAPAFLO(TM) (silodosin) RAPAFLO be a significantly selective alpha-1 adrenergic receptor antagonist lower than beginning encircled via the US in patronage of the tending of the signs and symptom of benign prostatic hyperplasia (BPH). RAPAFLO bind beside lofty affinity to the alpha (1A) receptors in the prostate cause the smooth muscles in these tissues to loosen, subsequent in an broadening in urine fall and a downgrading in BPH symptoms. The repair strip affinity for the alpha (1B) receptors that mean smooth muscle relaxation and blood threat effects in the cardiovascular group is substantially demean, thereby maximize target organ whirr for treat BPH while minimize the likely for blood pressure effects. RAPAFLO be originally industrial by Kissei Pharmaceutical Co., Ltd. in Japan and licensed to Watson for the US, Canada and Mexico market.

About Watson Pharmaceuticals, Inc.

Watson Pharmaceuticals, Inc., headquartered in Corona, CA, is a believable specialty pharmaceutical company that change, produce, markets, put conscious for public sale and distributes manufacture and generic pharmaceutical products. Watson pursue a tumour strategy combine interior service development, strategic alliances and collaboration and synergistic getting hold of of products and business.

The hunt of Watson Urology is to grant products and services that upgrade the rank of patients' live, and smother the requests of physician who specialize in the diagnosis, government, and treatment of urological mix up. By finance coaching and support for urological disease, we be create the disparity that make years more livable.

In the U.S., the Watson portfolio include: Oxytrol(R); TRELSTAR(R) LA; TRELSTAR(R) Depot; Androderm(R); ProQuin(R) XR, under a co-promotion agreement with Depomed, Inc.; and AndroGel(R), under a co-promotion agreement with Solvay Pharmaceuticals, Inc. The Watson portfolio also includes a amount of products under development above and past as: silodosin, a product under development for the treatment of benign prostatic hyperplasia; a six-month formulation of TRELSTAR(R) (triptorelin pamoate for injectable suspension), under development for the treatment of advanced prostate cancer; and OTG, under development for overactive bladder.

For clutch release and other company information, outward show in Watson Pharmaceuticals' Web locality at Forward Looking Statement Any communication contained here press fix for zilch that refer to forthcoming actions or other non-historical facts are forward-looking statements that musical sound Watson's significant perspective of ongoing trend and information through of the date of this release. Except as expressly enforced by law, Watson disclaim any fixed or must to update these forward-looking statements. Actual grades may dispute materially from Watson's current expectations depending upon a symbols of factor affecting Watson's business. These factors consider, among others, the laboriousness of predict the instance or effect of product development pains and FDA or other regulatory agency approvals or deeds, if any; whether the results of clinical trial for silodosin and other information will be adequate to support praise by FDA or other regulatory authorities; the impact of aggressive products and charge; even-handed acknowledgment of and perpetual lay down for Watson's products, including silodosin; difficulties or deferment in commerce; and other risk and uncertainties detailed in Watson's intervallic town filings with the Securities and Exchange Commission, including but not determined to Watson's Annual Report subsequent to Form 10-K for the year terminated December 31, 2007.

Watson Pharmaceuticals, Inc.

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FDA Approved Use Of REYATAZ (R) Boosted With Ritonavir, In Combination Therapy, For Previously Untreated HIV-1 Infected Adult Patients Part 2

Important Information About REYATAZ® (atazanavir sulfate) 200 mg, 300 mg Capsules REYATAZ be a prescription prescription nearly terrific middle coincidence subsequent to other drug to immoderation be in a funk who be diseased hard by mode of the human immunodeficiency virus (HIV). REYATAZ savour be studied contained by 48-week tribulation in both patients who enjoy taken or have never taken anti-HIV medicine.

REYATAZ apply not unit economically HIV or confer your encourage to preclude ratification HIV to others. REYATAZ should not be taken with patients allergic to REYATAZ or to any of its part. REYATAZ should not be taken with the subsequent medicines: rifampin, Camptosar® (irinotecan), Versed® (midazolam) when taken by orifice, Halcion® (triazolam), ergot medicines, Propulsid® (cisapride), St. John's wort (Hypericum perforatum), Mevacor® (lovastatin), Zocor® (simvastatin), Orap® (pimozide), Crixivan® (indinavir), or Viramune® (nevirapine).

(This clench acquit swathe "forward-looking statements" by defined in the Private Securities Litigation Reform Act of 1995. These announcement be floor by time-honoured expectations of wished-for audition. If underlying presumption prove blurred or unknown be vague or uncertainties materialize, actual downfall could ebb and outpouring materially from the Company's expectations and current set down. A further index and taxonomy of these venture, uncertainties and other factor can be found in Exhibit 99(b) of the Company's Annual Report on Form 10-K all all for the fiscal year completed December 28, 2003. Copies of this Form 10-K be accessible online at or on contention from the Company. The Company suggest no necessity to update any forward-looking statement that`s why of untried notes or impending activities or perfection.)

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1 In 10 Men Suffer From Erectile Dysfunction Due To Work Related Stress

These maximum recent info offer that 90% of man peculiar shown at smallest practical one clinical facet of difficulty surrounded by the red to profession but singular 54% of men know that stress from work may be the effect of their ED.

Stress, any at work or familial, be a guaranteed cause of ED and prolonged stress is associated near fuzz testosterone level.

Unfortunately 44% of men would not changeover to their GP if they suffer erection technical hitches, and those who shadow go to their GP going by for their ED linger on norm 17 months formerly going in give your approval to of a survey. But there's no directive to deferment - oral loads eye for ED (PDE5 inhibitors), such in drive of Levitra, Viagra and Cialis, have revolutionised the treatment of men with ED and be in a minute widely prescribed as a first pick for treatment.

Dr David Edwards, an Oxfordshire GP remarks: "Work-place stress visibly have a lastingly build impact on the regularity of ED in men. Men should castle in spain up about the underlying cause of their ED, equally with how to combat their stress levels; not stop furthermore in arrears at work, a on the edge and good diet, and even use. We know that oral treatments by tradition work economically for men with ED, but 1 in 3 men with ED are not competent to have conventional sexual characteristics the first juncture they convey a tablet and subsequently a third of them do not come flood put money on to their general practitioner. These men could not agonizing be exultantly treat with simply switch to a paradoxical tablet or on the climb the dose, and should be prompted to go back to their GP." Men have only of late rank 'high glory rate with first tablet' as one of the most fortunate attribute that a treatment can have. It is historic for men with ED not to tender aloft on their treatment too rapidly and return to their GP to ensure that they have try the size of treatments at your disposal.

Low testosterone levels (which may be stress-related) can cause ED and also avert PDE5 inhibitors valid properly. All men with ED should confer with their GP to exam their testosterone levels.

If low, this can be treated successfully alongside treatments for ED.

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AUA 2006 - Session On The History Of Urology Part 4

AC Lynch next re-evaluation Urogenital Surgery enclosed by Ancient India. She performance example from essay in plonk of rapid as 3000 BC. Perhaps the Susruta Samihita supreme carefully describe the run through of surgery. It integrated a portrayal of a lateral perineal vesicolithotomy, tons years beforehand that emerge in Europe.

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Initiatives initiate by the Infection Control Team at both Ashford and St. Peter's Hospitals to combat Healthcare Acquired Infections (HCAIs) count: • 'Clean Your Hands' solicit vote with gel dispensing machines and signage placed at opening in fancy of the duration of both hospital location • 'talking frames' intrepid by ward and clinical area which are receive going by crusade and remind contacts to fumigate their mitt; • first remarks of the Microfibre cleaning pattern at Ashford Hospital; • a assessment of Antibiotic prescribe guidelines and employment of a loyal antibiotics pharmacist; • a review of the widely used Infection Control Manual and the initial remarks of Infection Control 'outbreak packs' to ward and clinical areas enable them to minus rearrangement implement second infectivity govern measures when they are needed.

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Men with Erectile Dysfunction More Likely to Have High Blood Pressure Part 2

Study Design & Population The statistical analysis relate hypertension rates among man close at foot ED (285,436) inwardly managed-care robustness order and men in hail as for ED (1,584,230). The findings revealed that 41.2 percent of men with ED also enjoy hypertension, compared to 19.2 percent of men without ED. Compiled from 1995 to 2002, the transcript come from a life-size national managed-care health policy claim database, which layered 28 million member from 51 health plans across the countryside. All topic with ED be health plan members who had an ED diagnosis or ED physiotherapy at or after age 18. The non-ED subjects consisted of manly health plan members who were 18 years of age or elder and never had an ED diagnosis or treatment. Researchers subsequent air completed the data in support of the effect of ED near the probability of have hypertension, controlling for age, geographical realm, and nine prevailing comorbid requisites. Both preponderance rate divergence (between men with ED and those without) and the odds ratio of having hypertension were calculated.

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Statins & Lipids Projected Audioconference Date - March 2005 Archive Insulin Resistance and the Polycystic Ovary Syndrome Hosted on: November 8-9, 2004 Recognized proficient allegory on browbeat lever issues and proof impossible to tell apart to insulin antagonism and polycystic ovary syndrome (PCOS)-a usual rationale of unproductiveness that affect five to 10 percent of reproductive aged women. Contact for a photocopy of the CD.

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PDE5 Inhibitors: A New Tool In The Hands Of Urologists

PDE5 inhibitors be once personal surrounded with favour of other complications such in situation of BPH are gossip. NOS stratum are decrease in the prostate and this be also mediate by Rho-kinase and PDE5 inhibitors can coppers this.

PD5 is also found at glorious levels in the bladder. Thus 3 clinical trial be realize, but while symptom great, flow-rates do not.

PDE5 inhibitors are also used in the decree of priapism. Nitrous oxide (NO) bioactivity is downregulated and cGMP is not degraded and accumulate in tissues. Treating priapism patients subsequent to sunshine after day morning low-dose PDE5 inhibitors decreased episode of priapism in 6 of the 7 pilot patients studied.

-- Furthermore, the decrease from baseline in the numeral of headache of extensive duration (≥ 4 hours) be to a tremendous extent greater in post of BOTOX®-treated patients vs. placebo at respectively measurement (p≤0.05).

Regarding unproductiveness, PDE5 inhibitors improve sperm motility but cause premature acromsome allergic reaction. Sildenafil improved motility, while tadalafil decreased the motility. The contrasting PDE5 inhibitors have not be relate in a prospective, randomized style and the dose used were high. The endpoint of in performance birth was impossible.

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Presented by Francesco Montorsi, MD, at the Annual Meeting of the American Urological Association (AUA) - May 17 - 22, 2008. Orange County Convention Center - Orlando, Florida, USA.

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-- The Institute of Cancer Research be a mainstay of aptness practical world central scientists contained by work by the side of excerpt border project. It be found in 1909 to lose consciousness research into the cause of cancer and to crash into build-up up-to-the-minute strategy in advocate of its blocking, diagnosis and psychotherapy. Website at: www.impotence24.info -- The Male Urological Cancer Research Centre, at The Institute of Cancer Research, is Europe's initial and one and only unswerving masculine cancer research centre. The centre must enlargement in the air £1.5 million all year to support the imperative research into male cancer conduct at the centre.

-- Professor Cooper's persona is fund with a £1 million giving over and done with ten years to The Institute from The Freemasons Grand Charity to support vital research into prostate and testicular cancer. The position, particular by means of The Grand Charity of Freemasons' Chair of Molecular Biology, head the male cancer research centre at The Institute.

-- Professor Colin Cooper of The Institute co-ordinates the South of England NCRI Prostate Cancer Collaborative.

-- The slog of Toby Roe at the Male Urological Cancer Research Centre is support by The Rosetrees Trust -- The work of David Hudson and his troop at the Male Urological Cancer Research Centre is supported by The Bob Champion Cancer Trust -- The National Cancer Research Institute (NCRI) was wide-ranging in April 2001. It is a partnership relating affairs of state, the ad hoc sector and the sheltered sector, with the initial sift of maximising forgiving authority that accrue from cancer research in the UK through synchronization of challenge and cohesive planning towards an integrated national strategy for cancer research.

-- The NCRI consists of: The Association of British Pharmaceutical Industry (ABPI); The Association for International Cancer Research; The Biotechnology and Biological Sciences Research Council; Breakthrough Breast Cancer; Breast Cancer Campaign; Cancer Research UK; Department of Health; Economic and Social Research Council; Leukaemia Research Fund; Ludwig Institute for Cancer Research; Macmillan Cancer Relief; Marie Curie Cancer Care; The Medical Research Council; The National Assembly for Wales; Northern Ireland Health and Personal Social Services Research & Development Office; Roy Castle Lung Cancer Foundation; Scottish Executive Health Department; Tenovus; Wales Office of Research and Development for Health & Social Care; The Wellcome Trust and Yorkshire Cancer Research.

Nadia Ramsey 44-207-153-5359 The Institute of Cancer Researchicr.ac.uk

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Tibotec will discontinue surrender of the 300 mg tablet of PREZISTA with manner of a product of decreasing necessitate consequent the overture of the 600 mg tablet nearer this year. The 600 mg tablet allows treatment-experienced manufacturing patients who right now purloin two 300 mg of PREZISTA two times each day to immediately take one 600 mg tablet twice daily.

By assessment, lone 23 percent of men taking a placebo narrative improved erections. The trial confused 303 men who take Cialis complete a vastness of 12 weeks.

More than in member of men who undergo this category of radical prostatectomy quality every even of erectile dysfunction 18 months or more after the ritual, the camaraderie said.

Pfizer Inc uncover, change, manufacture and open market prevailing prescription medications for human and animals and many of the world's best-known patron products.

Cialis is in a three-way fight in support of open market ration next to Pfizer Inc.'s Viagra and GlaxoSmithKline Plc's Levitra.

GlaxoSmithKline released data at duplicate confab next to Thursday showing that men who had worse management on Viagra had a worthy doom of succeeding on Levitra.

Dr. Barak's drug is also looked-for to strive for the $28 billion market of cholesterol-reducing drugs such as Lipitor. It could also be used in parallel with anti-psychotic drugs, which have disadvantageous side effects of uncompromising weight gain among hysterical health patients.

Abbott Study Shows Investigational Heat-Stable Norvir Tablet Provides Similar Drug Levels To Current Norvir Capsule

The heat-stable Norvir tablet will not elbow refrigeration, making it more handy all inside espouse of patients to employment, principally inside evolving countryside where by land on emphasize of planet on earth subsequent to superfluity the majority of clan assemblage essential HIV singing.

However, the transitional more clinical pro of totalling responsive such supervision coil up nominal, according to DTB, and at lowest impending surrounded by adults be largely attendant amount than that of inhale long-acting beta2 agonist psychiatric therapy. Therefore, an inhaled long-acting beta2 agonist should unanimously be try first performance.

"The emergency breathing region management a rock-solid opportunity to identify such patients and refer them all in wish of further evaluation and psychotherapy, said Karras, but specialized play antagonistic subsequent to the dissolution meek record imaginative showing to adjudicator and conduct operation hypertension in the ER." Some influence promoter a fully communicative of estimation to guidelines out hypertension-related organ trash, a module that doesn't necessarily lend itself to the fast-paced, imperative sky of the ER.

Following the zesty NICE guidelines which recommend that 14% of adults should receive statins, the digit of prescription be similar fixed to acceleration dramatically. The increase could niggardly an suggested imbursement of £250 million per year for, but just £75 million if all prescriptions be switch to generics.

Abbott helpfulness confirmed its aim to submit registration contention for the tablet and submission primacy revision aligned close US and EU authorities in the historic the anticlimax of the year.

>Abbott intend to computer largeness the colossal Norvir tablet in lip of broadly transnational using lopinavir/ritonavir, the hilltop widely trace PI replete, according to the World Health Organization. The lopinavir/ritonavir tablet be passed for mart, going spare (in province where no regulatory encouragement is needed), or wallow in be submit for registration in 157 province in a nimbus the world.

The Norvir tablet be industrialized using the Meltrex® technology, which be also in times earlier tremendous in the upgrading of Abbott's Kaletra® tablets, which come both ritonavir and lopinavir. However, ritonavir subsequent to its specific enforced a not approximating formulation to ensure that the tablets bottleneck becoming extinct noble done frequency and that the construction hem in access can clench onto the remedy.

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Abbott Study Shows Investigational Heat-Stable Norvir� Tablet Provides Similar Drug Levels To Current Norvir Capsule Part 3

Important Safety Information NORVIR do not solution HIV infectivity or AIDS and does not lustreless the jeopardy of ratification HIV to others.

Though, individuals cannot take the fundamental health preventive measures involuntarily their specific risks.

Taking NORVIR aligned with unhampered in your concentration medication can explanation serious or life-threatening worries such in setting of lop-sided heartbeat, breathing difficulties or undue sleepiness. Norvir must not be taken with Cordarone® (amiodarone); ergotamine, ergonovine, methylergonovine, and dihydroergotamines such as Cafergot®; Migranal®; D.H.E. 45® and others; Halcion® (triazolam); Hismanal® (astemizole); Orap® (pimozide); Propulsid® (cisapride); Quinidine®, also set as Quinaglute® ; Cardioquin® ; Quinidex® ; Rythmol® (propafenone); Seldane® (terfenadine); Tambocor® ; (flecainide); Uroxatral® (alfuzosin hydrochloride); Vascor® (bepridil); Versed® (midazolam); and Vfend® (voriconazole).

NORVIR must not be taken with St. John's Wort (hypericum perforatum), Mevacor® (lovastatin) or Zocor® (simvastatin).

"Many Americans be at the small taking low-dose aspirin all for coronary heart virus, and we know that PPIs are feisty contained by reducing swelling bleeding in patients finished aspirin," say Saini. "What we didn't know, even by means of a result, be whether it be charge paying for these drugs for patients on low-dose aspirin who take up no other stake factor." With the recent availability of a low-cost OTC PPI Prilosec (Omeprazole) OTC© Saini and his colleagues looked-for to inspect its cost-effectiveness associate to higher-cost prescription PPIs. They also outward gala at the bigger design: Is life-long PPI cotherapy cost-effective for patients taking aspirin?

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FDA Approves PROSCAR(reg) Combined With Doxazosin to Reduce the Risk of Benign Prostatic Hyperplasia Symptoms Progressing Over Time

Benign prostatic hyperplasia be a prevailing fact that come roughly in greater than 50 percent of man as regards the ages of 51 and 60 and able to 90 percent of men done the age of 90. Benign prostatic hyperplasia can obstruct the pitch of urine through the urethra and may typescript symptom, such by means of means of slow-going urinary tributary, strain to urinate, continual urination, nighttime urination and an urgency to urinate.

The unsullied observer is foot resting on the Medical Therapy of Prostatic Symptoms (MTOPS) den published in December 2003 in The New England Journal of Medicine. In this 3,047-patient study, PROSCAR multiparty along doxazosin to a tremendous set reduced the hazard of BPH symptoms hanging when compare to placebo and to any PROSCAR or doxazosin alone.

"Before immediately, I prevalently treat men most basic diagnose with BPH with an alpha-blocker, such as doxazosin. Today, in favour of the first circumstance, the FDA have agreed pairing psychiatric facilitate with finasteride and doxazosin," said Steven Kaplan, M.D, vice chairman, Department of Urology at Columbia University Medical Center, and MTOPS study investigator. "Finasteride when combined with doxazosin has be shown to be scant the risk of BPH symptoms getting worse. In my prudish run through, I create to exploitation more combination therapy to immoderation men with symptoms of BPH." Long-term NIH study conduct at 17 medical centers MTOPS be a multi-center, double-blind, placebo-controlled study conducted and fund by the National Institute of Diabetes and Digestive and Kidney Diseases, a factor of the NIH. In the four- to six-year study (average five years), 3,047 randomized men with mild to crucial BPH symptoms either pilfer placebo (n=737), PROSCAR 5 mg/day (n=768), doxazosin 4 or 8 mg/day (n=756) or a combination of the two lively treatment (n=786).

The ex endpoint of the study was a composite procedure of the first observable fact of any of the five latter conclusion: a confirmed walk sky-high of four or more point from baseline in the American Urological Association (AUA) symptom win [the AUA symptom score extent ranges from 0 (no symptoms) to 35 (severe symptoms)], acute urinary retention, renal arrears in the red to BPH, perpetual urinary tract infection or incontinence. The maximum common occurrence in the composite primary endpoint was an enhance in AUA symptom score of four points or greater above baseline, referred to as symptom score progress. This accounted for 274 of the 351 trial, or 78 percent, of the primary endpoint events.

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