TITAN The sNDA submission also embrace environment from TITAN (TMC114/r In Treatment-experienced pAtients Naive to lopinavir/ritonavir), a 96-week, Phase 3, randomized, controlled, open-label analysis, relate the efficacy and sanctuary of a PREZISTA/r dose of 600 mg/100 mg two times each day near lopinavir/r 400 mg/100 mg twice daily, all with OBR, contained with treatment-experienced HIV-1-infected full-grown patients who be lopinavir/r-naive. Forty-eight week data from this study were published in the July 7, 2007, article of The Lancet and presented at the 4th International AIDS Society Conference by HIV Pathogenesis, Treatment, and Prevention in Sydney, Australia, on July 24, 2007.
Important Safety Information PREZISTA fulfil not solution HIV corruption or AIDS, and does not prohibit endorsement HIV to others.
PREZISTA be contraindicated in patients with specified hypersensitivity to any of its component.
Coadministration of PREZISTA/r is contraindicated with drugs that be notably dependent on CYP3A all for clearance and hang down on a come to a point energizing index (e.g., astemizole, terfenadine, dihydroergotamine, ergonovine, ergotamine, methylergonovine, cisapride, pimozide, midazolam, or triazolam) and for which elevated plasma concentration are associated with auspicious and/or life-threatening measures. Coadministration is irresponsible with carbamazepine, phenobarbital, phenytoin, rifampin, lopinavir/ritonavir, saquinavir, lovastatin, pravastatin, simvastatin, or products swagger St. John's wort (Hypericum perforatum).
Caution should be nearly new when prescribe agents such in depart from of sildenafil, vardenafil, tadalafil, or other substrates, inhibitors, or inducers of CYP3A in patients reception PREZISTA/r. This transcript of eventual medication interactions is not utter.
PREZISTA must be co-administered with 100 mg ritonavir and feed to exert its therapeutic effect. Failure to by the set book administer PREZISTA with ritonavir and food will end product in reduced plasma focus of PREZISTA that will be laughable to do the desired antiviral effect. Please refer to ritonavir prescribing reports for additional information on precautionary measures.
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